Article
PTEN mutations and microsatellite instability in complex atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma.
Cancer research - 1 Aug 1998
Levine R L, Cargile C B, Blazes M S, van Rees B, Kurman R J, Ellenson L H
Abstract excerpt
The two most common types of genetic alterations yet identified in uterine endometrioid carcinoma (UEC) are PTEN mutations and microsatellite instability (MI). Furthermore, MI-positive UECs (defined as tumors with detectable alterations at two or more different microsatellite loci) are significantly more likely to contain PTEN mutations than are MI-negative UECs. To determine whether PTEN inactivation is a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.