Article
PTEN mutations and microsatellite instability in complex atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma.
Cancer research - 1 Aug 1998
Levine R L, Cargile C B, Blazes M S, van Rees B, Kurman R J, Ellenson L H
Abstract excerpt
The two most common types of genetic alterations yet identified in uterine endometrioid carcinoma (UEC) are PTEN mutations and microsatellite instability (MI). Furthermore, MI-positive UECs (defined as tumors with detectable alterations at two or more different microsatellite loci) are significan...
Topics
- Carcinoma, Endometrioid
- DNA, Neoplasm
- Endometrial Hyperplasia
- Exons
- Female
- Genes, Tumor Suppressor
- Humans
- Microsatellite Repeats
- Mutation
- Phenotype
- Precancerous Conditions
- Protein Tyrosine Phosphatases
- Retrospective Studies
- Uterine Neoplasms