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Article

Immunohistochemistry and Next-generation Sequencing Are Complementary Tests in Identifying PTEN Abnormality in Endometrial Carcinoma Biopsies.

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists - 1 Jan 2022

Wang Linyuan, Piskorz Anna, Bosse Tjalling, Jimenez-Linan Mercedes, Rous Brian, Gilks C Blake, Brenton James D, Singh Naveena, Köbel Martin

Abstract excerpt

PTEN plays a central role in the pathogenesis of endometrial carcinoma. Previous studies reported a high interobserver reproducibility for the interpretation of PTEN immunohistochemistry (IHC). However, PTEN IHC and its interpretation remain challenging during laboratory practice. The purpose of this study was to reevaluate PTEN IHC pattern in direct comparison to next-generation sequencing in identifying PTEN...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33720084
DOI: 10.1097/PGP.0000000000000763

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