Article
Novel mutations of CYP3A4 in Chinese.
Drug metabolism and disposition: the biological fate of chemicals - 1 Mar 2001
Hsieh K P, Lin Y Y, Cheng C L, Lai M L, Lin M S, Siest J P, Huang J D
Abstract excerpt
Human cytochrome P450 3A4 is a major P450 enzyme in the liver and gastrointestinal tract. It plays important roles in the metabolism of a wide variety of drugs, some endogenous steroids, and harmful environmental contaminants. CYP3A4 exhibits a remarkable interindividual activity variation as high as 20-fold. To investigate whether the interindividual variation in CYP3A4 levels can be partly explained by genetic...
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