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Article

CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity.

Clinical pharmacology and therapeutics - 1 Jan 2000

Sata F, Sapone A, Elizondo G, Stocker P, Miller V P, Zheng W, Raunio H, Crespi C L, Gonzalez F J

Abstract excerpt

OBJECTIVE: To determine the existence of mutant and variant CgammaP3A4 alleles in three racial groups and to assess functions of the variant alleles by complementary deoxyribonucleic acid (cDNA) expression. METHODS: A bacterial artificial chromosome that contains the complete CgammaP3A4 gene was isolated and the exons and surrounding introns were directly sequenced to develop primers to polymerase chain reaction...

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Identifiers

PMID: 10668853
DOI: 10.1067/mcp.2000.104391

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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