Article
Identification and Functional Assessment of Eight CYP3A4 Allelic Variants *39-*46 Detected in the Chinese Han Population.
Drug metabolism and disposition: the biological fate of chemicals - 14 Feb 2024
Qi Yuying, Yang Hang, Wang Shuanghu, Zou Lili, Zhao Fangling, Zhang Qing, Hong Yun, Luo Qingfeng, Zhou Quan, Geng Peiwu, Chen Hao, Ji Fusui, Cai Jianping, Dai Dapeng
Abstract excerpt
Cytochrome P450 3A4 (CYP3A4), a key enzyme, is pivotal in metabolizing approximately half of the drugs used clinically. The genetic polymorphism of the CYP3A4 gene significantly influences individual variations in drug metabolism, potentially leading to severe adverse drug reactions (ADRs). In this study, we conducted a genetic analysis on CYP3A4 gene in 1163 Chinese Han individuals to identify the genetic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.