Article
Genetic polymorphism of cytochrome P450 3A5 in Chinese.
Drug metabolism and disposition: the biological fate of chemicals - 1 Sept 2001
Chou F C, Tzeng S J, Huang J D
Abstract excerpt
The CYP3A subfamily enzymes are the most abundant and important drug-metabolizing enzymes. Wide variation in the CYP3A5 expression was well known. Recently, G(-44) to A of CYP3AP1 was found to segregate with CYP3A5*3 defective allele. The homozygous A(-44) subjects showed low expression of CYP3A5. In Caucasian, only 9.2% of CYP3AP1 alleles were with G(-44) and associated with the wild-type CYP3A5*1 allele, which...
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