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Article

Functional gene variants of CYP3A4.

Clinical pharmacology and therapeutics - 1 Sept 2014

Werk A N, Cascorbi I

Abstract excerpt

Cytochrome P450 3A4 (CYP3A4) is involved in the metabolism of more drugs in clinical use than any other foreign compound-metabolizing enzyme in humans. Recently, increasing evidence has been found showing that variants in the CYP3A4 gene have functional significance and--in rare cases--lead to loss of activity, implying tremendous consequences for patients. This review article highlights the functional...

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PMID: 24926778
DOI: 10.1038/clpt.2014.129

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