Article
Analysis of CYP3A4 genetic polymorphisms in Han Chinese.
Journal of human genetics - 1 Jun 2011
Zhou Qing, Yu Xiaomin, Shu Chang, Cai Yimei, Gong Wei, Wang Xumin, Wang Duen-mei, Hu Songnian
Abstract excerpt
Our study aimed to comprehensively investigate the genetic polymorphisms of CYP3A4 in Han Chinese. We sequenced the gene regions of CYP3A4, including its promoter, exons, surrounding introns and 3' untranslated region (3'UTR), from 100 unrelated-healthy Han Chinese individuals. We detected 11 SNPs, three of which are novel. According to in silico functional prediction of novel variants, 20148 A>G in exon 10,...
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