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Article

Power comparisons between the TDT and two likelihood-based methods.

Genetic epidemiology - 1 Feb 2001

Slager S L, Huang J, Vieland V J

Abstract excerpt

We compare the statistical power of the transmission disequilibrium test (TDT) with that of two likelihood-based linkage tests, the classical LOD score and a modified LOD score in which a linkage disequilibrium (LD) parameter is incorporated into the likelihood (LD-LOD). We hypothesize that, when LD is present, the LD-LOD will have the greatest power of the three tests because the TDT breaks a multiplex pedigree...

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Identifiers

PMID: 11180446
DOI: 10.1002/1098-2272(200102)20:2<192::AID-GEPI3>3.0.CO;2-X

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