Article
A test for linkage and association in general pedigrees: the pedigree disequilibrium test.
American journal of human genetics - 1 Jul 2000
Martin E R, Monks S A, Warren L L, Kaplan N L
Abstract excerpt
Family-based tests of linkage disequilibrium typically are based on nuclear-family data including affected individuals and their parents or their unaffected siblings. A limitation of such tests is that they generally are not valid tests of association when data from related nuclear families from larger pedigrees are used. Standard methods require selection of a single nuclear family from any extended pedigrees...
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