A test for linkage and association in general pedigrees: the pedigree disequilibrium test.

doi:10.1086/302957

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Article

A test for linkage and association in general pedigrees: the pedigree disequilibrium test.

American journal of human genetics - 1 Jul 2000

Martin E R, Monks S A, Warren L L, Kaplan N L

Abstract excerpt

Family-based tests of linkage disequilibrium typically are based on nuclear-family data including affected individuals and their parents or their unaffected siblings. A limitation of such tests is that they generally are not valid tests of association when data from related nuclear families from larger pedigrees are used. Standard methods require selection of a single nuclear family from any extended pedigrees...

Topics

Alleles
Chromosome Mapping
Computer Simulation
Female
Genetic Diseases, Inborn
Genotype
Humans
Linkage Disequilibrium
Male
Models, Genetic
Nuclear Family
Pedigree
Penetrance
Prevalence
Reproducibility of Results
Research Design
Sample Size
Statistical Distributions

Source

Open in PubMed Open full text

Identifiers

PMID: 10825280
DOI: 10.1086/302957
PMCID: PMC1287073

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