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Article

Glutamate receptor dysregulation in the hippocampus of transgenic mice carrying mutated human amyloid precursor protein.

Neurobiology of disease - 1 Feb 2001

Cha J H, Farrell L A, Ahmed S F, Frey A, Hsiao-Ashe K K, Young A B, Penney J B, Locascio J J, Hyman B T, Irizarry M C

Abstract excerpt

Alzheimer's disease transgenic mice overexpressing human amyloid precursor protein (hAPP) with the Swedish double mutation (hAPP(Sw)) develop age-related amyloid deposition and behavioral and electrophysiologic changes by an unknown mechanism. Analysis of glutamatergic receptor subtypes in 4- and 15-month-old heterozygous hAPP(Sw) transgenic mice revealed a selective increase in AMPA receptor binding in the...

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Source

Identifiers

PMID: 11162243
DOI: 10.1006/nbdi.2000.0330

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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