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Article

Altered neurotransmitter receptor expression in transgenic mouse models of Huntington's disease

29 Jun 1999

Abstract excerpt

Alterations in neurotransmitter receptors are a pathological hallmark of the neurodegeneration seen in Huntington's disease (HD). However, the significance of these alterations has been uncertain, possibly reflecting simply the loss of brain cells. It is not known for certain whether the alteration of neurotransmitter receptors occurs before the onset of symptoms in human HD. Recently we developed transgenic mice...

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PMID: 10434296
DOI: 10.1098/rstb.1999.0449

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