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Article

Region- and age-specific changes in glutamate transport in the AβPP23 mouse model for Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2011

Schallier Anneleen, Smolders Ilse, Van Dam Debby, Loyens Ellen, De Deyn Peter Paul, Michotte Alex, Michotte Yvette, Massie Ann

Abstract excerpt

Using 8- and 18-month-old AβPP23 mice, we investigated the involvement of high-affinity glutamate transporters (GLAST, GLT-1, EAAC1), vesicular glutamate transporters (VGLUT1-3) and xCT, the specific subunit of system x(c)⁻, in Alzheimer's disease (AD) pathogenesis. Transporter expression was studied in cortical and hippocampal tissue and linked to extracellular glutamate and glutamate reuptake activity as...

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PMID: 21297271
DOI: 10.3233/JAD-2011-101005

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