Article
Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jul 2001
Fitzjohn S M, Morton R A, Kuenzi F, Rosahl T W, Shearman M, Lewis H, Smith D, Reynolds D S, Davies C H, Collingridge G L, Seabrook G R
Abstract excerpt
We have studied synaptic function in a transgenic mouse strain relevant to Alzheimer's disease (AD), overexpressing the 695 amino acid isoform of human amyloid precursor protein with K670N and M671L mutations (APP(695)SWE mice), which is associated with early-onset familial AD. Aged-transgenic mice had substantially elevated levels of Abeta (up to 22 micromol/gm) and displayed characteristic Abeta plaques....
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