Article
Testing for gene-gene interaction controlling total IgE in families from Barbados: evidence of sensitivity regarding linkage heterogeneity among families.
Genomics - 15 Jan 2001
Barnes K C, Mathias R A, Nickel R, Freidhoff L R, Stockton M L, Xue X, Naidu R P, Levett P N, Casolaro V, Beaty T H
Abstract excerpt
Genetic heterogeneity has been proposed as a hallmark feature of allergic disease. To test the hypothesis that total IgE levels are jointly influenced by a locus on chromosome 12q21.1-q21.31 and a locus on 17q11.2-q21.2, we conducted multipoint allele-sharing analyses using nonparametric linkage (NPL) methods on Afro-Caribbean families from Barbados to test for evidence of gene-gene interactions. Significant...
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