Article
Genome-wide association study and admixture mapping reveal new loci associated with total IgE levels in Latinos.
The Journal of allergy and clinical immunology - 1 Jun 2015
Pino-Yanes Maria, Gignoux Christopher R, Galanter Joshua M, Levin Albert M, Campbell Catarina D, Eng Celeste, Huntsman Scott, Nishimura Katherine K, Gourraud Pierre-Antoine, Mohajeri Kiana, O'Roak Brian J, Hu Donglei, Mathias Rasika A, Nguyen Elizabeth A, Roth Lindsey A, Padhukasahasram Badri, Moreno-Estrada Andres, Sandoval Karla, Winkler Cheryl A, Lurmann Fred, Davis Adam, Farber Harold J, Meade Kelley, Avila Pedro C, Serebrisky Denise, Chapela Rocio, Ford Jean G, Lenoir Michael A, Thyne Shannon M, Brigino-Buenaventura Emerita, Borrell Luisa N, Rodriguez-Cintron William, Sen Saunak, Kumar Rajesh, Rodriguez-Santana Jose R, Bustamante Carlos D, Martinez Fernando D, Raby Benjamin A, Weiss Scott T, Nicolae Dan L, Ober Carole, Meyers Deborah A, Bleecker Eugene R, Mack Steven J, Hernandez Ryan D, Eichler Evan E, Barnes Kathleen C, Williams L Keoki, Torgerson Dara G, Burchard Esteban G
Abstract excerpt
BACKGROUND: IgE is a key mediator of allergic inflammation, and its levels are frequently increased in patients with allergic disorders. OBJECTIVE: We sought to identify genetic variants associated with IgE levels in Latinos. METHODS: We performed a genome-wide association study and admixture mapping of total IgE levels in 3334 Latinos from the Genes-environments & Admixture in Latino Americans (GALA II) study....
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