Article
Human L1 retrotransposition: cis preference versus trans complementation.
Molecular and cellular biology - 1 Feb 2001
Wei W, Gilbert N, Ooi S L, Lawler J F, Ostertag E M, Kazazian H H, Boeke J D, Moran J V
Abstract excerpt
Long interspersed nuclear elements (LINEs or L1s) comprise approximately 17% of human DNA; however, only about 60 of the approximately 400,000 L1s are mobile. Using a retrotransposition assay in cultured human cells, we demonstrate that L1-encoded proteins predominantly mobilize the RNA that encodes them. At much lower levels, L1-encoded proteins can act in trans to promote retrotransposition of mutant L1s and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.