No consistent pattern of mutations in p53 and ras genes in liver tumors of rat treated with the drinking water mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX).

doi:10.1002/1098-2280(2000)36:4<292::aid-em5>3.0.co;2-3

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Article

No consistent pattern of mutations in p53 and ras genes in liver tumors of rat treated with the drinking water mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX).

Environmental and molecular mutagenesis - 1 Jan 2000

Komulainen H, Hakulinen P, Servomaa K, Makkonen K, Vasara R, Mäki-Paakkanen J, Kosma V M

Abstract excerpt

The frequency of point mutations in p53 (exons 4-7) and in Ki-ras, Ha-ras, and N-ras (exons 1 and 2) and the expression of p53 protein were evaluated in the liver tumors of Wistar rats of a 104-week carcinogenicity study on 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a chlorine disinfection by-product in drinking water. Mutations were analyzed in 16 hepatocellular adenomas, 7 hepatocellular...

Topics

Animals
Base Sequence
DNA Primers
Female
Furans
Genes, p53
Genes, ras
Immunohistochemistry
Liver Neoplasms, Experimental
Male
Mutagens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Polymerase Chain Reaction

Polymorphism, Single-Stranded Conformational

Proliferating Cell Nuclear Antigen

Rats

Rats, Wistar

Water Supply

Source

Open in PubMed

Identifiers

PMID: 11152562
DOI: 10.1002/1098-2280(2000)36:4<292::aid-em5>3.0.co;2-3

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-11152562-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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