Article
Screening for p53 mutations in C3H/He mouse liver tumors derived spontaneously or induced with diethylnitrosamine or phenobarbitone.
Molecular carcinogenesis - 1 Feb 1994
Rumsby P C, Davies M J, Evans J G
Abstract excerpt
Distinct differences have been described in the development of C3H/He mouse liver tumors induced by the genotoxic carcinogen diethylnitrosamine (DEN) and by the nongenotoxic agent phenobarbitone (PB) in terms of pathology and the frequency of mutation at codon 61 of the Ha-ras oncogene. To furthe...
Topics
- Animals
- Base Sequence
- DNA, Neoplasm
- DNA, Single-Stranded
- Diethylnitrosamine
- Exons
- Genes, p53
- Liver Neoplasms, Experimental
- Mice
- Mice, Inbred C3H
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Phenobarbital
- Polymerase Chain Reaction
- Polymorphism, Genetic