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Article

Hepatic mRNA, microRNA, and miR-34a-target responses in mice after 28 days exposure to doses of benzo(a)pyrene that elicit DNA damage and mutation.

Environmental and molecular mutagenesis - 1 Jan 2012

Malik Amal I, Williams Andrew, Lemieux Christine L, White Paul A, Yauk Carole L

Abstract excerpt

Benzo(a)pyrene (BaP) is a mutagenic carcinogen that is ubiquitous in our environment. To better understand the toxic effects of BaP and to explore the relationship between toxicity and toxicogenomics profiles, we assessed global mRNA and microRNA (miRNA) expression in Muta™Mouse. Adult male mice were exposed by oral gavage to 25, 50, and 75 mg/kg/day BaP for 28 days. Liver tissue was collected 3 days following...

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Identifiers

PMID: 21964900
DOI: 10.1002/em.20668
PMCID: PMC3525943

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Source receipt: pubmed, retrieved 7 Sept 2026.

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