Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53 mutations in hepatocellular carcinomas induced by a choline-devoid diet in male Fischer 344 rats.

Carcinogenesis - 1 Mar 1993

Smith M L, Yeleswarapu L, Scalamogna P, Locker J, Lombardi B

Abstract excerpt

Analyses were performed on livers and hepatocellular carcinomas from male Fischer 344 rats fed a choline-devoid diet, to assess whether they carried alterations of the p53 tumor suppressor gene. The analyses consisted of immunoperoxidase staining of tissue sections with monoclonal antibodies to p53, Western blotting and cDNA sequencing. Immunostaining revealed the presence of mutant p53 proteins in 22/27 tumors...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Genes, p53
Share to Liver Neoplasms, Experimental

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Rats, Inbred F344

Source

Identifiers

PMID: 8453727
DOI: 10.1093/carcin/14.3.503

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53 mutations in hepatocellular carcinomas induced by a choline-devoid diet in male Fischer 344 rats.PMID 8453727Read ↗

A mutational hot spot in the p53 gene is associated with hepatoblastomas.Semantic proximity Read ↗

Absence of p16, p21 and p53 gene alterations in hepatocellular carcinomas induced by N-nitrosodiethylamine or a choline-deficient L-amino acid-defined diet in rats.Semantic proximity Read ↗

Potential role of p53 mutation in chemical hepatocarcinogenesis of rats.Semantic proximity Read ↗

Different frequencies and patterns of beta-catenin mutations in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient L-amino acid-defined diet in rats.Semantic proximity Read ↗

p53 mutations are absent from carcinogen-induced mouse liver tumors but occur in cell lines established from these tumors.Semantic proximity Read ↗

p53 Mutations in human hepatocellular carcinomas from Germany.Semantic proximity Read ↗

No consistent pattern of mutations in p53 and ras genes in liver tumors of rat treated with the drinking water mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX).Semantic proximity Read ↗

Loss of p53 function in colon cancer cells results in increased phosphocholine and total choline.Semantic proximity Read ↗

Mutation and expression of the p53 gene during chemical hepatocarcinogenesis in F344 rats.Semantic proximity Read ↗

Analysis of the p53 tumor-suppressor gene in hepatocellular carcinomas from Britain.Semantic proximity Read ↗

Lack of p53 accelerates hepatocarcinogenesis in transgenic mice constitutively overexpressing c-myc in the liver.Semantic proximity Read ↗

Screening for p53 mutations in C3H/He mouse liver tumors derived spontaneously or induced with diethylnitrosamine or phenobarbitone.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.