Article
Murine p53 intron sequences 5-8 and their use in polymerase chain reaction/direct sequencing analysis of p53 mutations in CD-1 mouse liver and lung tumors.
Molecular carcinogenesis - 1 Jan 1992
Goodrow T L, Storer R D, Leander K R, Prahalada S R, van Zwieten M J, Bradley M O
Abstract excerpt
Inactivating point mutations and small deletions in the p53 tumor suppressor gene have been found in human liver and lung tumor--derived cell lines and tumors. However, little evidence has been reported concerning inactivation or mutation of the p53 gene in mouse primary tumors. To examine CD-1 mouse liver and lung tumors for mutations in the p53 gene, we first sequenced p53 introns 5-8 so that polymerase chain...
Topics
- Animals
- Base Sequence
- Introns
- Liver Neoplasms
- Lung Neoplasms
- Mice
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction
- Tumor Suppressor Protein p53