Article
Assessment of the genotoxicity of the rat carcinogen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in rat liver epithelial cells in vitro.
Toxicology in vitro : an international journal published in association with BIBRA - 1 Mar 2008
Mäki-Paakkanen J, Hakulinen P
Abstract excerpt
3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a disinfection by-product in chlorinated drinking water, is a multisite carcinogen in rats. One main target organ is the liver. The mechanism of the tumorigenicity was evaluated by testing the genotoxicity of MX in rat liver epithelial ce...
Topics
- Animals
- Carcinogens
- Cell Line
- Cell Survival
- Comet Assay
- DNA Damage
- Dose-Response Relationship, Drug
- Epithelial Cells
- Furans
- Hypoxanthine Phosphoribosyltransferase
- Liver
- Mutagens
- Mutation
- Rats
- Rats, Inbred F344