p53 mutation is infrequent and might not give a growth advantage in rat bladder carcinogenesis in vivo.

doi:10.1093/carcin/15.3.455

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Article

p53 mutation is infrequent and might not give a growth advantage in rat bladder carcinogenesis in vivo.

Carcinogenesis - 1 Mar 1994

Asamoto M, Mann A M, Cohen S M

Abstract excerpt

Abnormalities of the p53 gene are frequently observed in human tumors, including urinary bladder carcinoma, suggesting that p53 plays an important role in human carcinogenesis. However, its role in rat bladder carcinogenesis is unclear. In this study, we investigated the presence of p53 mutations...

Topics

Animals
Base Sequence
Codon
Exons
Genes, p53
Male
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Rats
Rats, Inbred F344
Urinary Bladder Neoplasms

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