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Article

p53 mutation is infrequent and might not give a growth advantage in rat bladder carcinogenesis in vivo.

Carcinogenesis - 1 Mar 1994

Asamoto M, Mann A M, Cohen S M

Abstract excerpt

Abnormalities of the p53 gene are frequently observed in human tumors, including urinary bladder carcinoma, suggesting that p53 plays an important role in human carcinogenesis. However, its role in rat bladder carcinogenesis is unclear. In this study, we investigated the presence of p53 mutations in 122 urinary bladder tumors induced in F344 rats in the following carcinogenesis models: (i) 0.2%...

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PMID: 8118928
DOI: 10.1093/carcin/15.3.455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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