Article
Potential role of p53 mutation in chemical hepatocarcinogenesis of rats.
World journal of gastroenterology - 1 Jan 2004
Deng Wei-Guo, Fu Yan, Li Yu-Lin, Sugiyama Toshihiro
Abstract excerpt
AIM: Inactivation of p53 gene is one of the most frequent genetic alterations in carcinogenesis. The mutation status of p53 gene was analyzed, in order to understand the effect of p53 mutation on chemical hepatocarcinogenesis of rats. METHODS: During hepatocarcinogenesis of rats induced by 3'-methyl-4- dimethylaminoazobenzene (3'-Me-DAB), prehepatocarcinoma and hepatocarcinoma foci were collected by laser capture...
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