Article
MX, a by-product of water chlorination, lacks in vivo genotoxicity in gpt delta mice but inhibits gap junctional intercellular communication in rat WB cells.
Environmental and molecular mutagenesis - 1 Jan 2006
Nishikawa Akiyoshi, Sai Kimie, Okazaki Kazushi, Son Hwa-Young, Kanki Keita, Nakajima Madoka, Kinae Naohide, Nohmi Takehiko, Trosko James E, Inoue Tohru, Hirose Masao
Abstract excerpt
3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a by-product of water chlorination, is a potent bacterial mutagen and rat carcinogen. In the present study, the in vivo mutagenicity, cell proliferative activity, and carcinogenicity of MX were investigated in gpt delta mice. Groups of 5 male and female 7-week-old gpt delta C57BL/6J transgenic mice were given MX at doses of 0, 10, 30, or 100 ppm in their...
Topics
- Animals
- Carcinogens
- Cell Communication
- Cell Line
- Chlorine
- Epithelial Cells
- Escherichia coli Proteins
- Female
- Furans
- Gap Junctions
- Liver
- Male
- Mice