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Article

Mechanisms of molecular recognition in the pikromycin polyketide synthase.

Chemistry & biology - 1 Dec 2000

Chen S, Xue Y, Sherman D H, Reynolds K A

Abstract excerpt

BACKGROUND: Modular polyketide synthases (PKSs) produce a wide range of medically significant compounds. In the case of the pikromycin PKS of Streptomyces venezuelae, four separate polypeptides (PikAI-PikAIV), comprising a total of one loading domain and six extension modules, generate the 14-membered ring macrolactone narbonolide. The polypeptide PikAIV contains a thioesterase (TE) domain and is responsible for...

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PMID: 11137814
DOI: 10.1016/s1074-5521(00)00039-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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