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Article

Protein–Protein Interactions in Multienzyme Megasynthetases

20 Mar 2008

Abstract excerpt

The multienzyme polyketide synthases (PKSs), nonribosomal polypeptide synthetases (NRPSs), and their hybrids are responsible for the construction in bacteria of numerous natural products of clinical value. These systems generate high structural complexity by using a simple biosynthetic logic--that of the assembly line. Each of the individual steps in building the metabolites is designated to an independently...

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PMID: 18357594
DOI: 10.1002/cbic.200700751

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