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Navigating the Fungal Polyketide Chemical Space: From Genes to Molecules

31 Aug 2012

Abstract excerpt

The iterative type I polyketide synthases (IPKSs) are central to the biosynthesis of an enormously diverse array of natural products in fungi. These natural products, known as polyketides, exhibit a wide range of biological activities and include clinically important drugs as well as undesirable toxins. The PKSs synthesize these structurally diverse polyketides via a series of decarboxylative condensations of...

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PMID: 22938194
DOI: 10.1021/jo301592k

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