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Article

Combinatorialization of fungal polyketide synthase-peptide synthetase hybrid proteins.

Journal of the American Chemical Society - 24 Dec 2014

Kakule Thomas B, Lin Zhenjian, Schmidt Eric W

Abstract excerpt

The programming of the fungal polyketide synthase (PKS) is quite complex, with a simple domain architecture leading to elaborate products. An additional level of complexity has been found within PKS-based pathways where the PKS is fused to a single module nonribosomal peptide synthetase (NRPS) to synthesize polyketides conjugated to amino acids. Here, we sought to understand the communication between these...

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PMID: 25436464
DOI: 10.1021/ja511087p

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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