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Article

The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.

15 Aug 1995

Abstract excerpt

The macrocyclic polyketides rapamycin and FK506 are potent immunosuppressants that prevent T-cell proliferation through specific binding to intracellular protein receptors (immunophilins). The cloning and specific alteration of the biosynthetic genes for these polyketides might allow the biosynthesis of clinically valuable analogues. We report here that three clustered polyketide synthase genes responsible for...

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PMID: 7644502
DOI: 10.1073/pnas.92.17.7839

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