Article
Engineering of an industrial polyoxin producer for the rational production of hybrid peptidyl nucleoside antibiotics.
Metabolic engineering - 1 Jul 2012
Zhai Lipeng, Lin Shuangjun, Qu Dongjing, Hong Xuechuan, Bai Linquan, Chen Wenqing, Deng Zixin
Abstract excerpt
Polyoxins and nikkomycins are potent antifungal peptidyl nucleoside antibiotics, which inhibit fungal cell wall biosynthesis. They consist of a nucleoside core and one or two independent peptidyl moieties attached to the core at different sites. Making mutations and introducing heterologous genes into an industrial Streptomyces aureochromogenes polyoxin producer, resulted in the production of four...
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