Article
Disruption of T cell signaling networks and development by Grb2 haploid insufficiency.
Nature immunology - 1 Jan 2001
Gong Q, Cheng A M, Akk A M, Alberola-Ila J, Gong G, Pawson T, Chan A C
Abstract excerpt
The developmental processes of positive and negative selection in the thymus shape the T cell antigen receptor (TCR) repertoire and require the integration of multiple signaling networks. These networks involve the efficient assembly of macromolecular complexes and are mediated by multimodular adaptor proteins that permit the functional integration of distinct signaling molecules. We show here that decreased...
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