Article
Signal-transducing adaptor molecules STAM1 and STAM2 are required for T-cell development and survival.
Molecular and cellular biology - 1 Dec 2002
Yamada Mitsuhiro, Ishii Naoto, Asao Hironobu, Murata Kazuko, Kanazawa Chieko, Sasaki Hidetada, Sugamura Kazuo
Abstract excerpt
We previously reported that the STAM family members STAM1 and STAM2 are phosphorylated on tyrosine upon stimulation with cytokines through the gammac-Jak3 signaling pathway, which is essential for T-cell development. Mice with targeted mutations in either STAM1 or STAM2 show no abnormality in T-cell development, and mice with double mutations for STAM1 and STAM2 are embryonically lethal; therefore, here we...
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