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Grb2 and GRAP connect the B cell antigen receptor to Erk MAP kinase activation in human B cells

5 Mar 2018

Abstract excerpt

The B cell antigen receptor (BCR) employs enzymatically inactive adaptor proteins to facilitate activation of intracellular signaling pathways. In animal model systems, adaptor proteins of the growth factor receptor-bound 2 (Grb2) family have been shown to serve critical functions in lymphocytes. However, the roles of Grb2 and the Grb2-related adaptor protein (GRAP) in human B lymphocytes remain unclear. Using...

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PMID: 29523808
DOI: 10.1038/s41598-018-22544-x

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