Article
Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis.
Cancer research - 1 Nov 2002
Cheung Alison M Y, Hande M Prakash, Jalali Farid, Tsao Ming-Sound, Skinnider Brian, Hirao Atsushi, McPherson J Peter, Karaskova Jana, Suzuki Akira, Wakeham Andrew, You-Ten Annick, Elia Andrew, Squire Jeremy, Bristow Rob, Hakem Razqallah, Mak Tak W
Abstract excerpt
BRCA2 is a breast cancer susceptibility gene of which the product is thought to be involved in monitoring genome integrity and cell cycle progression. Brca2-null mice have a defect in embryonic cellular proliferation and die in utero. Here we report the generation of T-cell lineage-specific Brca2-deficient (tBrca2(-/-)) mice using the Cre-loxP system. Mice with a flanked by loxP allele of Brca2 were crossed to...
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