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Article

Loss of c-Cbl RING finger function results in high-intensity TCR signaling and thymic deletion.

The EMBO journal - 2 Nov 2005

Thien Christine B F, Blystad Frøydis D, Zhan Yifan, Lew Andrew M, Voigt Valentina, Andoniou Christopher E, Langdon Wallace Y

Abstract excerpt

Signaling from the T-cell receptor (TCR) in thymocytes is negatively regulated by the RING finger-type ubiquitin ligase c-Cbl. To further investigate this regulation, we generated mice with a loss-of-function mutation in the c-Cbl RING finger domain. These mice exhibit complete thymic deletion by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16211006
DOI: 10.1038/sj.emboj.7600841
PMCID: PMC1276723

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16211006-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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