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Article

TRIB2 regulates normal and stress-induced thymocyte proliferation

15 Mar 2016

Abstract excerpt

TRIB2, a serine/threonine pseudokinase identified as an oncogene, is expressed at high levels in the T-cell compartment of hematopoiesis. The proliferation of developing thymocytes is tightly controlled to prevent leukemic transformation of T cells. Here we examine Trib2 loss in murine hematopoiesis under steady state and proliferative stress conditions, including genotoxic and oncogenic stress. Trib2 (-/-)...

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Identifiers

PMID: 27462446
DOI: 10.1038/celldisc.2015.50

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