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Article

Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila.

Proceedings of the National Academy of Sciences of the United States of America - 2 Jan 2001

Struhl G, Greenwald I

Abstract excerpt

The cleavage model for signal transduction by receptors of the LIN-12/Notch family posits that ligand binding leads to cleavage within the transmembrane domain, so that the intracellular domain is released to translocate to the nucleus and activate target gene expression. The familial Alzheimer's disease-associated protein Presenilin is required for LIN-12/Notch signaling, and several lines of evidence suggest...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 11134525
DOI: 10.1073/pnas.98.1.229
PMCID: PMC14573

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila.PMID 11134525Read ↗

Presenilin is required for activity and nuclear access of Notch in Drosophila.Semantic proximity Read ↗

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila.Semantic proximity Read ↗

Notch receptor cleavage depends on but is not directly executed by presenilins.Semantic proximity Read ↗

Drosophila presenilin is required for neuronal differentiation and affects notch subcellular localization and signaling.Semantic proximity Read ↗

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.Semantic proximity Read ↗

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations.Semantic proximity Read ↗

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.Semantic proximity Read ↗

Nuclear access and action of notch in vivo.Semantic proximity Read ↗

Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.Semantic proximity Read ↗

Drosophila nicastrin is essential for the intramembranous cleavage of notch.Semantic proximity Read ↗

Presenilins: molecular switches between proteolysis and signal transductionSemantic proximity Read ↗

Identification and characterization of presenilin-independent Notch signaling.Semantic proximity Read ↗

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