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Article

Presenilin is required for activity and nuclear access of Notch in Drosophila.

Nature - 8 Apr 1999

Struhl G, Greenwald I

Abstract excerpt

Presenilins are membrane proteins with multiple transmembrane domains that are thought to contribute to the development of Alzheimer's disease by affecting the processing of beta-amyloid precursor protein. Presenilins also facilitate the activity of transmembrane receptors of the LIN-12/Notch family. After ligand-induced processing, the intracellular domain of LIN-12/Notch can enter the nucleus and participate in...

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Identifiers

PMID: 10206646
DOI: 10.1038/19091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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Presenilin is required for activity and nuclear access of Notch in Drosophila.PMID 10206646Read ↗

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.Semantic proximity Read ↗

Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila.Semantic proximity Read ↗

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations.Semantic proximity Read ↗

Drosophila presenilin is required for neuronal differentiation and affects notch subcellular localization and signaling.Semantic proximity Read ↗

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila.Semantic proximity Read ↗

Nuclear access and action of notch in vivo.Semantic proximity Read ↗

Presenilin-based genetic screens in Drosophila melanogaster identify novel notch pathway modifiers.Semantic proximity Read ↗

Notch receptor cleavage depends on but is not directly executed by presenilins.Semantic proximity Read ↗

Endosomal entry regulates Notch receptor activation in Drosophila melanogaster.Semantic proximity Read ↗

Identification and characterization of presenilin-independent Notch signaling.Semantic proximity Read ↗

Drosophila nicastrin is essential for the intramembranous cleavage of notch.Semantic proximity Read ↗

Presenilins: molecular switches between proteolysis and signal transductionSemantic proximity Read ↗

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