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Article

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

Nature - 8 Apr 1999

Ye Y, Lukinova N, Fortini M E

Abstract excerpt

Presenilin proteins have been implicated both in developmental signalling by the cell-surface protein Notch and in the pathogenesis of Alzheimer's disease. Loss of presenilin function leads to Notch/lin-12-like mutant phenotypes in Caenorhabditis elegans and to reduced Notch1 expression in the mouse paraxial mesoderm. In humans, presenilins that are associated with Alzheimer's disease stimulate overproduction of...

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Share to Amyloid beta-Protein Precursor
Share to Intracellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Photoreceptor Cells, Invertebrate

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Share to Protein Processing, Post-Translational

Share to Receptors, Cell Surface

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Source

Identifiers

PMID: 10206647
DOI: 10.1038/19096

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.PMID 10206647Read ↗

Drosophila presenilin is required for neuronal differentiation and affects notch subcellular localization and signaling.Semantic proximity Read ↗

Presenilin-based genetic screens in Drosophila melanogaster identify novel notch pathway modifiers.Semantic proximity Read ↗

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations.Semantic proximity Read ↗

Presenilin is required for activity and nuclear access of Notch in Drosophila.Semantic proximity Read ↗

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila.Semantic proximity Read ↗

Drosophila nicastrin is essential for the intramembranous cleavage of notch.Semantic proximity Read ↗

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.Semantic proximity Read ↗

Presenilins, processing of beta-amyloid precursor protein, and notch signaling.Semantic proximity Read ↗

Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.Semantic proximity Read ↗

Identifying genes that interact with Drosophila presenilin and amyloid precursor protein.Semantic proximity Read ↗

The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals.Semantic proximity Read ↗

Independent and cooperative action of Psen2 with Psen1 in zebrafish embryos.Semantic proximity Read ↗

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