Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

doi:10.1038/19096

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Article

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

Nature - 8 Apr 1999

Ye Y, Lukinova N, Fortini M E

Abstract excerpt

Presenilin proteins have been implicated both in developmental signalling by the cell-surface protein Notch and in the pathogenesis of Alzheimer's disease. Loss of presenilin function leads to Notch/lin-12-like mutant phenotypes in Caenorhabditis elegans and to reduced Notch1 expression in the mouse paraxial mesoderm. In humans, presenilins that are associated with Alzheimer's disease stimulate overproduction of...

Topics

Alzheimer Disease
Amyloid beta-Protein Precursor
Animals
Binding Sites
Blotting, Western
Drosophila
Drosophila Proteins
Female
Humans
Intracellular Signaling Peptides and Proteins
Male
Membrane Proteins
Mutagenesis
Mutation
Phenotype
Photoreceptor Cells, Invertebrate
Presenilins
Protein Processing, Post-Translational

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PMID: 10206647
DOI: 10.1038/19096

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