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Article

Drosophila presenilin is required for neuronal differentiation and affects notch subcellular localization and signaling.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Oct 1999

Guo Y, Livne-Bar I, Zhou L, Boulianne G L

Abstract excerpt

Presenilins are a highly conserved family of proteins first identified as causative genes in early onset familial Alzheimer's disease. Recent studies have suggested a role for presenilins in the Notch-signaling pathway, but their specific function within this pathway remains unclear. Here, we have characterized the Drosophila presenilin gene and protein and studied their interaction with Notch in both mutants and...

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Identifiers

PMID: 10493744
PMCID: PMC6783002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Drosophila presenilin is required for neuronal differentiation and affects notch subcellular localization and signaling.PMID 10493744Read ↗

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