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Article

Drosophila nicastrin is essential for the intramembranous cleavage of notch.

Developmental cell - 1 Jan 2002

López-Schier Hernán, St Johnston Daniel

Abstract excerpt

The catalytic subunit of gamma-secretase is thought to be Presenilin, which is required for both the cleavage of APP and in the processing of Notch. Presenilin is found in a multisubunit complex that also contains Nicastrin. Nicastrin has been implicated in APP processing, but its role in Notch signaling remains unclear. Here we show that Drosophila Nicastrin is required for Notch signaling, and acts specifically...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11782316
DOI: 10.1016/s1534-5807(01)00109-5

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drosophila nicastrin is essential for the intramembranous cleavage of notch.PMID 11782316Read ↗

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor.Semantic proximity Read ↗

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila.Semantic proximity Read ↗

Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals.Semantic proximity Read ↗

Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model.Semantic proximity Read ↗

Presenilin-based genetic screens in Drosophila melanogaster identify novel notch pathway modifiers.Semantic proximity Read ↗

Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.Semantic proximity Read ↗

Nicastrin binds to membrane-tethered Notch.Semantic proximity Read ↗

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.Semantic proximity Read ↗

Mutations in nicastrin protein differentially affect amyloid beta-peptide production and Notch protein processing.Semantic proximity Read ↗

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.Semantic proximity Read ↗

The presenilins.Semantic proximity Read ↗

The levels of mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein.Semantic proximity Read ↗

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