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Article

Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2003

Micchelli Craig A, Esler William P, Kimberly W Taylor, Jack Christine, Berezovska Oksana, Kornilova Anna, Hyman Bradley T, Perrimon Norbert, Wolfe Michael S

Abstract excerpt

Signaling from the Notch (N) receptor is essential for proper cell-fate determinations and tissue patterning in all metazoans. N signaling requires a presenilin (PS)-dependent transmembrane-cleaving activity that is closely related or identical to the gamma-secretase proteolysis of the amyloid-beta precursor protein (APP) involved in Alzheimer's disease pathogenesis. Here, we show that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12424225
DOI: 10.1096/fj.02-0394fje

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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