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Article

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila.

Nature cell biology - 1 Dec 2001

Chung H M, Struhl G

Abstract excerpt

The transmembrane glycoprotein Nicastrin was identified in a complex with the multipass membrane protein Presenilin. Presenilin mediates transmembrane cleavage of single-pass transmembrane proteins with short extracellular domains, including the ligand-activated form of the receptor Notch and beta-amyloid precursor protein (beta-APP). Transmembrane cleavage of Notch is essential for signal transduction, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11781576
DOI: 10.1038/ncb1201-1129

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila.PMID 11781576Read ↗

Drosophila nicastrin is essential for the intramembranous cleavage of notch.Semantic proximity Read ↗

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor.Semantic proximity Read ↗

Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals.Semantic proximity Read ↗

Presenilin-based genetic screens in Drosophila melanogaster identify novel notch pathway modifiers.Semantic proximity Read ↗

Nicastrin binds to membrane-tethered Notch.Semantic proximity Read ↗

Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model.Semantic proximity Read ↗

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.Semantic proximity Read ↗

The presenilins.Semantic proximity Read ↗

Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.Semantic proximity Read ↗

Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila.Semantic proximity Read ↗

Loss of nicastrin elicits an apoptotic phenotype in mouse embryos.Semantic proximity Read ↗

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.Semantic proximity Read ↗

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