Article
Identification and characterization of presenilin-independent Notch signaling.
The Journal of biological chemistry - 8 Mar 2002
Berechid Bridget E, Kitzmann Magali, Foltz Daniel R, Roach Arthur H, Seiffert Dietmar, Thompson Lorin A, Olson Richard E, Bernstein Alan, Donoviel Dorit B, Nye Jeffrey S
Abstract excerpt
Presenilin (PS) proteins control the proteolytic cleavage that precedes nuclear access of the Notch intracellular domain. Here we observe that a partial activation of the HES1 promoter can be detected in PS1/PS2 (PS1/2) double null cells using Notch1 Delta E constructs or following Delta 1 stimulation, despite an apparent abolition of the production and nuclear accumulation of the Notch intracellular domain....
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