Article
Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice.
Immunity - 1 Aug 2000
Grandea A G, Golovina T N, Hamilton S E, Sriram V, Spies T, Brutkiewicz R R, Harty J T, Eisenlohr L C, Van Kaer L
Abstract excerpt
Loading of peptides onto major histocompatibility complex class I molecules involves a multifactorial complex that includes tapasin (TPN), a membrane protein that tethers empty class I glycoproteins to the transporter associated with antigen processing. To evaluate the in vivo role of TPN, we have generated Tpn mutant mice. In these animals, most class I molecules exit the endoplasmic reticulum (ER) in the...
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