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Article

Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP.

Immunity - 1 Aug 1996

Sadasivan B, Lehner P J, Ortmann B, Spies T, Cresswell P

Abstract excerpt

Assembly of MHC class I-beta 2 microglobulin (beta 2m) dimers in the endoplasmic reticulum involves two chaperones. Calnexin has previously been shown to interact with free class I heavy chains. Here, we show that the related chaperone, calreticulin, binds human class I-beta 2m dimers prior to peptide loading. Calreticulin remains associated with at least a subset of class I molecules when they, in turn, bind to...

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Identifiers

PMID: 8769474
DOI: 10.1016/s1074-7613(00)80487-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP.PMID 8769474Read ↗

Calreticulin and calnexin interact with different protein and glycan determinants during the assembly of MHC class I.Semantic proximity Read ↗

Mutant MHC class I molecules define interactions between components of the peptide-loading complex.Semantic proximity Read ↗

Critical role for the tapasin-docking site of TAP2 in the functional integrity of the MHC class I-peptide-loading complex.Semantic proximity Read ↗

Assembly of tapasin-associated MHC class I in the absence of the transporter associated with antigen processing (TAP).Semantic proximity Read ↗

Soluble tapasin restores MHC class I expression and function in the tapasin-negative cell line .220.Semantic proximity Read ↗

The cell biology of major histocompatibility complex class I assembly: towards a molecular understandingSemantic proximity Read ↗

Distinct patterns of folding and interactions with calnexin and calreticulin in human class I MHC proteins with altered N-glycosylation.Semantic proximity Read ↗

Class I MHC molecules: assembly and antigen presentation.Semantic proximity Read ↗

Recruitment of MHC class I molecules by tapasin into the transporter associated with antigen processing-associated complex is essential for optimal peptide loading.Semantic proximity Read ↗

Lectin-deficient calreticulin retains full functionality as a chaperone for class I histocompatibility molecules.Semantic proximity Read ↗

Calnexin recognizes carbohydrate and protein determinants of class I major histocompatibility complex molecules.Semantic proximity Read ↗

Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice.Semantic proximity Read ↗

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