Article
Increased AT(1) receptors in adrenal gland of AT(2) receptor gene-disrupted mice.
Regulatory peptides - 15 Oct 2001
Saavedra J M, Armando I, Terrón J A, Falcón-Neri A, Jöhren O, Häuser W, Inagami T
Abstract excerpt
Angiotensin II (Ang II) AT(2) receptor-gene disrupted mice have increased systemic blood pressure and response to exogenous Angiotensin II. To clarify the mechanism of these changes, we studied adrenal AT(1) receptor expression and mRNA by receptor autoradiography and in situ hybridization in female AT(2) receptor-gene disrupted mice (agtr 2-/-) and wild-type controls (agtr 2+/+). We found high expression of...
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