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Article

The VITA Project: heritability of resistance to activated protein C. Vincenza Thrombophilia and Arteriosclerosis.

Thrombosis and haemostasis - 1 Nov 2000

Tosetto A, Castaman G, Cappellari A, Rodeghiero F

Abstract excerpt

Resistance to activated protein C (APC) is a risk factor for venous thromboembolism also in absence of the FV Leiden mutation. To evaluate the influence of genetic factors on APC resistance, we evaluated the heritability of the APC resistance phenotype in 1,519 sib-parent pairs randomly selected from the VITA Project. After adjustment for known influencing factors, a high heritability coefficient (0.58) was...

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Source

Identifiers

PMID: 11127861

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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